1-(4-tert-Butylbenzyl)pyrimidine-2,4(1H,3H)-dione
نویسندگان
چکیده
The asymmetric unit of the title compound, C(15)H(18)N(2)O(2), contains two independent mol-ecules with essentially identical geometries and conformations. The dihedral angles between the benzene and pyrimidine rings in the two mol-ecules are 89.96 (11) and 73.91 (11)°. The six methyl groups are disordered over two sets of sites, with site occupancies of 0.545 (4):0.455 (4) and 0.542 (7):0.458 (7) in the two mol-ecules. The crystal structure is stabilized by N-H⋯O hydrogen bonds.
منابع مشابه
1,3-Bis(4-tert-butylbenzyl)pyrimidine-2,4(1H,3H)-dione
In the crystal structure of the title mol-ecule, C(26)H(32)N(2)O(2), the six methyl groups are disordered over two positions, with site-occupancy ratios of 0.665 (8):0.335 (8) and 0.639 (8):0.361 (8). The central pyrimidine ring is almost planar with an r.m.s. deviation of 0.009 Å. The dihedral angles formed by the two benzene rings with the pyrimidine ring are 70.70 (8) and 88.02 (9)°. The dih...
متن کاملSynthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe(2+)-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of...
متن کامل1,3-Bis(4-methoxybenzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
The title compound, C(21)H(22)N(2)O(4), was prepared by reaction of 6-methyl-pyrimidine-2,4(1H,3H)-dione and 1-chloro-methyl-4-meth-oxy-benzene. In the title mol-ecule, the central pyrimidine ring forms dihedral angles of 62.16 (4) and 69.77 (3)° with the two benzene rings. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into chains.
متن کامل6-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione monohydrate
The title compound, C(5)H(3)F(3)N(2)O(2)·H(2)O, was prepared by the reaction of ethyl 4,4,4-trifluoro-3-oxobutano-ate with urea. In the crystal, the 6-(trifluoro-meth-yl)pyrimidine-2,4(1H,3H)-dione and water mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds. A ring dimer structure is formed by additional inter-molecular N-H⋯O hydrogen bonds.
متن کاملSynthesis of azanucleosides through regioselective ring-opening of epoxides catalyzed by sulphated zirconia under microwave and solvent-free conditions.
New azanucleosides were obtained using sulphated zirconia (ZS) as catalyst in the nucleophilic oxirane ring opening reaction of 1-allyl-3-(oxiran-2-ylmethyl) pyrimidine-2,4(1H,3H)-dione and 1-allyl-5-methyl-3-(oxiran-2-ylmethyl)-pyrimidine-2,4(1H,3H)-dione, with (S)-prolinol. The new templates were obtained with good yields following a route which exploits the reactivity of epoxides in the pres...
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عنوان ژورنال:
دوره 68 شماره
صفحات -
تاریخ انتشار 2012